GLP-1 Cost Comparison Calculator

GLP-1 Medication Pricing in 2026

GLP-1 receptor agonist medications have transformed weight management and diabetes treatment, but their costs remain a significant barrier for many patients. Brand-name options like Ozempic and Wegovy (semaglutide) from Novo Nordisk, and Mounjaro and Zepbound (tirzepatide) from Eli Lilly, carry retail prices ranging from $950 to $1,350 per month without insurance. This calculator helps you compare costs across all major GLP-1 options based on your insurance status and location, so you can make an informed decision with your healthcare provider.

Insurance Coverage for Weight Loss Medications

Insurance coverage for GLP-1 medications varies dramatically depending on the indication. If prescribed for type 2 diabetes, Ozempic and Mounjaro are typically covered with copays ranging from $25 to $150 per month. However, when prescribed for weight loss, coverage is much more limited. Many private insurance plans and Medicare do not cover Wegovy or Zepbound for obesity treatment, leaving patients to pay full retail price. Medicaid coverage varies by state. Check with your specific plan before starting treatment, as formulary coverage and prior authorization requirements change frequently.

Manufacturer Savings Programs and Coupons

Both Novo Nordisk and Eli Lilly offer manufacturer savings programs that can significantly reduce out-of-pocket costs. Commercially insured patients may qualify for savings cards that bring copays down to as low as $25 per month. Eli Lilly also offers Zepbound through its LillyDirect program at self-pay prices of $399 to $549 per month. These programs typically exclude patients on government insurance (Medicare, Medicaid, Tricare). Eligibility requirements and program terms change regularly, so verify current availability directly with the manufacturer.

Compounded GLP-1 Medications Explained

Compounded versions of semaglutide and tirzepatide have emerged from compounding pharmacies at significantly lower prices — typically $150 to $500 per month. These became available during FDA-declared drug shortages. However, compounded medications are not FDA-approved and quality can vary between pharmacies. The FDA has stated that the semaglutide shortage has been resolved, which may affect the legal availability of compounded versions. If considering compounded options, discuss the risks and benefits with your healthcare provider and ensure the pharmacy is accredited.

Comparing Value: Cost Per Kilogram Lost

Price alone does not tell the full story. Clinical trials show different levels of efficacy across GLP-1 medications. Wegovy produces average weight loss of about 15% of body weight, while Zepbound (tirzepatide) has shown approximately 22.5% average loss in trials. When you factor in these efficacy differences, the cost per kilogram of weight lost can shift the value equation significantly. A more expensive medication that produces substantially more weight loss may actually offer better value per kilogram lost. This calculator estimates cost-per-kg using published clinical trial averages to help you compare true value alongside price.